People >> Tobias Sikosek
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| Name: |
Tobias Sikosek |
| Status: |
PhD student |
| Email: |
t.sikosek uni-muenster.de |
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Current research interests (also see research page )
- evolution of protein structure and function
- evolution by gene duplication (neo-/subfunctionalisation)
- evolutionary computer simulations, lattice proteins
- protein stability/disorder/folding
- structural bioinformatics
- catalytic promiscuity and experimental evolution of enzymes
Curriculum
- 2000-2006: studies in biology, philosophy and computer sciences at the University of Muenster; focus on practical and theoretical evolutionary biology, molecular cell biology and bioinformatics.
- 2004-2005: study abroad year at the University of Auckland, New Zealand ; courses in microbiology, immunology, biochemistry and ecology.
- 2006-2007:
Diplom (MSc equivalent) thesis "The evolution of heterodimerising transcription factor
networks." in the group of Evolutionary Bioinformatics in Muenster under the supervision of Amelie Veron and Erich Bornberg-Bauer.
- 2008 - present: PhD project "The resolution of adaptive conflicts in protein evolution by shifts in thermodynamic stability and gene duplication"
- June 2010: research stay in Prof Hue Sun Chan's lab, University of Toronto
Conferences and workshops attended
Awards
Technical skills:
- Programming: Java, Python, Linux bash
- Structural Bioinformatics: FoldX, Rosetta, PyMol, Chimera, PDB, CATH, python scripting
- Bioinformatics: BLAST, sequence alignment, database search, phylogeny
- Visualization/Illustration: Inkscape, Cinema 4D, Matplotlib (Python), Mayavi (Python), Prefuse (Java)
- Wetlab: basic molecular biology
Teaching/course co-ordination
- 2006-2010: teaching practicals "Bioinformatics 2 - sequence analysis" (since 2008 also course co-ordination); contents: sequence alignments, phylogenies, protein structure prediction
- 2009: project design and co-supervision of BSc thesis: "Testing a single-copy plasmid system for
Protein Evolution Experiments" by Dieter Weber
- Jan 2010: BSc course "Modern Methods in Evolutionary Biology" - lecture entitled: "Structural evolution and subfunctionalisation of proteins"
- Dec 2010: MSc research project "A mutational path connecting two proteins"
- Feb 2011: BSc advanced project "Characterisation of the mutational energy landscape for the structural switch in Arc repressor"
Publications
- T. Sikosek, E. Bornberg-Bauer, and H.S. Chan
Evolutionary dynamics on bi-stability landscapes have the potential to resolve adaptive conflicts.
submitted
- T. Sikosek, H.S. Chan, and E. Bornberg-Bauer
Escape from Adaptive Conflict follows from weak functional trade-offs and mutational robustness.
submitted
- E. Bornberg-Bauer, A.-K. Huylmans, and T. Sikosek
How do new proteins arise?
Current Opinion in Structural Biology (2010) 20(3):390-39.
Scientific social networks
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